Anticoagulant and antithrombotic activities of modified xylofucan sulfate from the brown alga Punctaria plantaginea
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- 作者：Nadezhda E. Ustyuzhaninaa ; Maria I. Bilana ; Alexey G. Gerbsta ; Natalia A. Ushakovab ; Eugenia A. Tsvetkovaa ; Andrey S. Dmitrenoka ; Anatolii I. Usova ; Nikolay E. Nifantieva ; nen@ioc.ac.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Punctaria plantaginea ; Fucan sulfate ; Anticoagulant ; Antithrombotic ; Thrombin ; Docking
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：826-833
- 全文大小：2021 K
文摘
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Chemical modifications of sulfated xylofucan gave derivatives with regular structure.
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Highly sulfated linear fucans inhibit clot formation and platelets aggregation.
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Persulfated fucans potentiate thrombin and factor Xa inhibition by ATIII.
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Docking study suggested formation of a ternary complex thrombin-ATIII-fucan.