Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple ‘Omic‿Layers

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• 作者：Katsuyuki Yugi¹ ; ² ; ^{yugi@bs.s.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroyuki Kubota³ ; ⁴ ; Atsushi Hatano¹ ; Shinya Kuroda¹ ; ⁵ ; ⁶ ; ^{skuroda@bs.s.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：trans-omics ; metabolome ; proteome ; omic data ; trans-ome-wide association study (trans-OWAS)
• 刊名：Trends in Biotechnology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：34
• 期：4
• 页码：276-290
• 全文大小：2682 K

文摘

We propose ‘trans-omic’ analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.