Autoregulation and neurovascular coupling in the optic nerve head

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• 作者：Daniele Prada ; PhD^a ; ^{dprada@iupui.edu" class="auth_mail" title="E-mail the corresponding author} ; Alon Harris ; MS ; PhD ; FARVO^b ; Giovanna Guidoboni ; PhD^a ; ^b ; ^c ; Brent Siesky ; PhD^b ; Amelia M. Huang ; BS^b ; Julia Arciero ; PhD^a
• 关键词：autoregulation in the optic nerve head ; neurovascular coupling ; ocular biomechanics and hemodynamics ; mechanical influences on autoregulation ; metabolic autoregulation ; effects of impaired blood flow regulation ; optic neuropathies ; glaucoma ; blood flow regulation modeling
• 刊名：Survey of Ophthalmology
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：61
• 期：2
• 页码：164-186
• 全文大小：2688 K

文摘

Impairments of autoregulation and neurovascular coupling in the optic nerve head play a critical role in ocular pathologies, especially glaucomatous optic neuropathy. We critically review the literature in the field, integrating results obtained in clinical, experimental, and theoretical studies. We address the mechanisms of autoregulation and neurovascular coupling in the optic nerve head, the current methods used to assess autoregulation—including measurements of optic nerve head blood flow (or volume and velocity)—blood flow data collected in the optic nerve head as pressure or metabolic demand is varied in healthy and pathologic conditions, and the current status and potential of mathematical modeling work to further the understanding of the relationship between ocular blood flow mechanisms and diseases such as glaucoma.