Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway

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• 作者：Runmei Li^a ; ^b ; Hui Li^a ; ^b ; Qian Sun^a ; ^b ; Liang Liu^a ; ^b ; Chen Zhang^a ; ^b ; Xiubao Ren^a ; ^b ; ^{rwziyi@yahoo.com}
• 关键词：HEK293 ; Human Embryonic Kidney 293 cells ; FBS ; Fetal bovine serum ; IDO ; Indoleamine 2 ; 3-dioxygenase ; IL ; interleukin ; PBMCs ; Peripheral blood monouclear cells ; TIL-Ts ; T cells of tumor infiltrating lymphocytes ; TCR ; T cell receptor
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：102-107
• 全文大小：1075 K
• 卷排序：81

文摘

A negative correlation between IDO and Vav1 was identified in tumor microenvironment. IDO inhibits the expression of Vav1, subsequent Vav1/Rac cascade. IDO suppresses initial TCR signaling.