Altered vesicular glutamate transporter distributions in the mouse cochlear nucleus following cochlear insult
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- 作者：A.N. Heeringaa ; R.A. Stefanescua ; Y. Raphaela ; S.E. Shorea ; b ; c ; sushore@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABR ; auditory brainstem response ; ANF ; auditory nerve fiber ; ANOVA ; analysis of variance ; AVCN ; anteroventral cochlear nucleus ; CN ; cochlear nucleus ; DCN ; dorsal cochlear nucleus ; DCN1 ; molecular layer of the dorsal cochlear nucleus ; DCN2 ; fusiform cell layer of the dorsal cochlear nucleus ; DCN3 ; deep layer of the dorsal cochlear nucleus ; EDTA ; ethylenediaminetetraacetic acid ; GCL ; granule cell lamina ; INT ; interstitial region ; PBS ; phosphate-buffered saline ; PVCN ; posteroventral cochlear nucleu
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：315
- 期：Complete
- 页码：114-124
- 全文大小：2167 K
文摘
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VGLUT1 decreases in magnocellular CN ipsilateral to cochlear insult.
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VGLUT2 increases in ipsilateral CN regions receiving non-auditory nerve input.
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VGLUT1 and VGLUT2 changes suggest cross-modal compensation after cochlear insult.
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VGLUT changes in mice provide impetus for using genetic tools in elucidating mechanisms of tinnitus.