Characterization of 27-hydroxy-13-desmethyl spirolide C and 27-oxo-13,19-didesmethyl spirolide C. Further insights into the complex Adriatic Alexandrium ostenfeldii toxin profile

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• 作者：Patrizia Ciminiello ; Carmela Dell’ ; Aversano ; Emma Dello Iacovo ; Ernesto Fattorusso ; Martino Forino ; Laura Grauso ; Luciana Tartaglione ; Franca Guerrini ; Laura Pezzolesi ; Rossella Pistocchi
• 关键词：Spirolide ; Alexandrium ostenfeldii ; Adriatic Sea ; NMR ; LC-MS
• 刊名：Toxicon
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：56
• 期：8
• 页码：1327-1333
• 全文大小：274 K

文摘

Alexandrium ostenfeldii is a widespread toxic dinoflagellate that has recently bloomed across the Adriatic Sea, seriously threatening both shellfish consumers and aquacultures. In 2007 we reported on preliminary studies carried out on field samples and cultures of A. ostenfeldii. At the time, along with three major spirolides – among which 27-hydroxy-13,19-didesmethyl spirolide C (3) proved to be a novel compound – a number of new minor spirolides were detected. Unfortunately, for all of them only Mass Spectrometry-based structural hypotheses could be ventured due to their very small amount. In the present paper we report on isolation and High Resolution Mass Spectrometry- and NMR-based structural elucidation of two of those minor spirolides detected in our previous study.