- 作者：脰zg眉r 陌lhan ; Nil眉fer 陌lhan ; Mesut Co艧kun ; Mutlu C谋han Da臒lio臒lu ; Esra Ayhan Tuzcu ; Emre Ayintap ; U臒urcan Kesk谋n ; H眉sey谋n 脰ks眉z
- 刊名：American Journal of Ophthalmology
- 出版年：December, 2013
- 年：2013
- 卷：156
- 期：6
- 页码：1120-1124.e3
- 全文大小：724 K
Purpose
To investigate effects of enoxaparin on postoperative inflammation in patients with moderate nonproliferative diabetic retinopathy (NPDR) and nuclear cataract.Design
Prospective masked controlled trial.
Methods
setting: Institutional practice. study population: The study included 51 eyes of 51 diabetes mellitus (DM) patients with moderate NPDR and grade 2-3 nuclear cataracts. Group 1 included randomly selected patients who received enoxaparin in balanced salt solution (BSS) during cataract surgery, while standard BSS was used in Group 2. observation procedure: Patients were followed up 1聽day, 1聽week, and 1 and 2聽months after the surgery. main outcome measures: Anterior chamber cell and flare.
Results
Postoperatively, 20 patients from Group 1 and 4 patients in Group 2 had less than a mean of 10 cells at day 1 (P聽= .012). At the first week, 20 patients from Group 1 and 10 patients from Group 2 had less than a mean of 10 cells (P聽= .004). When compared for flare, 20 patients from Group 1 and 8 patients from Group 2 had a flare between 0 and聽+1 at postoperative day 1 (P聽< .001). By the end of postoperative first week, 24 patients from Group 1and 18 patients from Group 2 had a flare between 0 and聽+1 (P聽= .012). There was no difference between groups in terms of postoperative inflammation at the first and second months after the surgery.
Conclusion
The results of the study suggest that enoxaparin added into the infusion fluid may reduce postoperative inflammation in patients with DM, and this result supports the anti-inflammatory effect of enoxaparin.