Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery
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- 作者：Laurence Ardouin1 ; 6 ; Hervé ; Luche1 ; 2 ; 6 ; Rabie Chelbi1 ; Sabrina Carpentier3 ; Alaa Shawket1 ; Fré ; dé ; ric Montanana Sanchis1 ; Camille Santa Maria2 ; Pierre Grenot2 ; Yannick Alexandre1 ; Claude Gré ; goire1 ; Anissa Fries1 ; Thien-Phong Vu Manh1 ; Samira Tamoutounour1 ; Karine Crozat1 ; Elena Tomasello1 ; Audrey Jorquera1 ; Even Fossum4 ; Bjarne Bogen4 ; Hiroaki Azukizawa5 ; Marc Bajenoff1 ; Sandrine Henri1 ; Marc Dalod1 ; dalod@ciml.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author ; Bernard Malissen1 ; 2 ; bernardm@ciml.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：45
- 期：2
- 页码：305-318
- 全文大小：5315 K
文摘
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Thymic XCR1+ DCs undergo a high maturation rate essential for central tolerance
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Thymic DCs express genes preventing establishment of tolerance against viruses
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Thymic and peripheral tolerogenic DC maturation involves identical molecular changes
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Tolerogenic DC maturation results in changes as complex as immunogenic DC maturation