The dissociation constants of the cytostatic bosutinib by nonlinear least-squares regression of multiwavelength spectrophotometric and potentiometric pH-titration data
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- 作者：Milan Melouna ; milan.meloun@upce.cz" class="auth_mail" title="E-mail the corresponding author ; Veronika Nečasová ; a ; Milan Javůrekb ; Tomá ; &scaron ; Peká ; rekc
- 关键词：Dissociation constants ; Bosutinib ; Spectrophotometric titration ; Potentiometric Titration ; SQUAD(84) SPECFIT/32 ; ESAB2M ; HYPERQUAD ; INDICES ; PALLAS
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 February 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：158-167
- 全文大小：2626 K
文摘
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Bosutinib treats adult patients with the positive chronic myeloid leukemia.
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Four dissociation constants of bosutinib were determined in 0.1 M KCl and 25 °C, 37 °C in a mixed aqueous-methanolic medium.
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Acid–base equilibria were studied with spectrophotometric and potentiometric titrations.
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The number of light-absorbing variously protonated species was estimated from the rank of the absorbance matrix.