Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

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• 作者：Raman K. Bakshi ; Qingmei Hong ; Rui Tang ; Rubana N. Kalyani ; Tanya MacNeil ; David H. Weinberg ; Lex H.T. Van der Ploeg ; Arthur A. Patchett and Ravi P. Nargund
• 关键词：Privileged structure ; Melanocortin-4
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：1 March 2006
• 年：2006
• 卷：16
• 期：5
• 页码：1130-1133
• 全文大小：122 K

文摘

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.