1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

详细信息    查看全文

• 作者：Bakshi ; Raman K. ; Hong ; Qingmei ; Olson ; J.T. ; Ye ; Zhixiong ; Sebhat ; Iyassue K. ; Weinberg ; David H. ; et. al.
• 关键词：MC-4 agonist ; Tic ; Obesity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2005
• 出版时间：July 15, 2005
• 年：2005
• 卷：15
• 期：14
• 页码：3430-3433
• 全文大小：188 K

文摘

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.