Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

详细信息    查看全文

• 作者：Anne E. Conway¹ ; ² ; ³ ; ¹⁰ ; Eric L. Van Nostrand¹ ; ² ; ¹⁰ ; Gabriel A. Pratt¹ ; ² ; ⁴ ; Stefan Aigner¹ ; ² ; Melissa L. Wilbert¹ ; ² ; Balaji Sundararaman¹ ; ² ; Peter Freese⁵ ; Nicole J. Lambert⁵ ; Shashank Sathe¹ ; ² ; Tiffany Y. Liang¹ ; ² ; Anthony Essex³ ; Severine Landais³ ; Christopher B. Burge⁵ ; D. Leanne Jones³ ; ⁶ ; ⁷ ; ^{leannejones@ucla.edu" class="auth_mail" title="E-mail the corresponding author} ; Gene W. Yeo¹ ; ² ; ⁸ ; ⁹ ; ^{geneyeo@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：19 April 2016
• 年：2016
• 卷：15
• 期：3
• 页码：666-679
• 全文大小：4896 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">Enhanced CLIP identifies thousands of reproducible IMP1, IMP2, and IMP3 binding sites

dd><dt class="label">•dt><dd>

d="p0015">IMP1 and IMP2 binding sites are highly correlated in 3′ UTRs of coding genes

dd><dt class="label">•dt><dd>

d="p0020">Integrins represent a key mechanism for IMP1 modulation of cell adhesion in hESCs

dd><dt class="label">•dt><dd>

d="p0025">Apoptosis of hESCs resulting from depletion of IMP1 is mediated by IMP1 target BCL2

dd>dl>