Oxidosqualene cyclase from Saccharomyces cerevisiae
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- 作者：Gianni Balliano ; Henrietta Dehmlow ; Simonetta Oliaro-Bosso ; Matilde Scaldaferri ; Silvia Taramino ; Franca Viola ; Giulia Caron ; Johannes Aebi ; Jean Ackermann
- 关键词：Oxidosqualene cyclase ; Lanosterol synthase ; Inhibitors ; Antiparasitic agents
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 February 2009
- 年：2009
- 卷：19
- 期：3
- 页码：718-723
- 全文大小：227 K
文摘
A series of 25 compounds, some of which previously were described as inhibitors of human liver microsomal oxidosqualene cyclase (OSC), were tested as inhibitors of Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana OSCs expressed in an OSC-defective strain of S. cerevisiae. The screening identified three derivatives particularly promising for the development of novel anti-Trypanosoma agents and eight derivatives for the development of novel anti-Pneumocystis agents.