A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma
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- 作者：Hai-Ying Zoua ; b ; Guo-Qing Lva ; b ; Li-Hua Daia ; b ; Xiu-Hui Zhana ; b ; Ji-Wei Jiaoa ; b ; Lian-Di Liaoa ; c ; Tai-Mei Zhoua ; d ; Chun-Quan Lia ; Bing-Li Wua ; b ; Li-Yan Xua ; c ; lyxu@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; En-Min Lia ; b ; nmli@stu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BAMBI ; BMP and activin membrane-bound inhibitor ; CCM ; conditioned cell medium ; CCL4 ; C-C motif chemokine ligand 4 ; CCL28 ; C-C motif chemokine ligand 28 ; CXCL3 ; C-X-C motif chemokine ligand 3 ; DAP ; 1 ; 5-diaminopentane ; ESCC ; esophageal squamous cell carcinoma ; ECM ; extracellular matrix ; EREG ; epiregulin ; GADD45G ; growth arrest and DNA damage inducible gamma ; JUN ; c-jun proto-oncogene ; LOX ; lysyl oxidase ; LOXL2 ; lysyl oxidase-like 2 ; LOXL2WT ; wild-type lysyl oxidase-like 2 ; LOXL2Δ72 ; a variant of l
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：85-98
- 全文大小：3668 K
文摘
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We have identified a novel splice variant of lysyl oxidase-like 2, termed LOXL2Δ72.
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LOXL2Δ72 has the same N- and C-termini as wild-type LOXL2, but lacks 72 nucleotides encoding 24 amino acids.
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LOXL2Δ72 is no longer secreted, and enzymatic activity is very low.
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LOXL2Δ72 promotes ESCC cell migration and invasion to a greater degree than LOXL2WT.
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LOXL2Δ72 may contribute to tumor progression via novel molecular mechanisms.