Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis
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- 作者：Baobing Zhao ; Yang Mei ; Jing Yang ; Peng Ji ; ji.peng@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Experimental Hematology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：10
- 页码：975-981
- 全文大小：2455 K
文摘
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Erythropoietin (Epo) induces reactive oxygen species (ROS) production in early-stage erythroblasts.
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Oxidative status is correlated with CD71 expression and the uptake of iron and transferrin.
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The ROS level decreases in the late stages of terminal erythropoiesis.
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The ROS scavenger promotes enucleation.