The effect of a lipid composition and a surfactant on the characteristics of the solid lipid microspheres and nanospheres (SLM and SLN)

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• 作者：Malgorzata Sznitowska ; ^{msznito@gumed.edu.pl} ; Eliza Wolska ; Helena Baranska ; Krzysztof Cal ; Justyna Pietkiewicz
• 关键词：Solid lipid nanoparticles ; Microparticles ; Surfactants ; Lipids ; Ultrasound
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：24-30
• 全文大小：2042 K
• 卷排序：110

文摘

Solid lipid microparticles (SLM) were produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their mixtures with Miglyol 812 or Witepsol H15 were used as lipid components (10–30% w/w). The average size of the SLM prepared with Compritol and Tween 80 as an emulsifier was 3–7 μm and the influence of lipid concentration and thermal sterilization was not large. Dispersions of SLM with Precirol (10–20% w/w) gellified upon storage. SLM stabilized with another surfactant, Tego Care 450, were larger in size and measured 40 μm on average. The use of the sonication step (5–15 min) in hot formulations containing 5% w/w of Compritol resulted in the formation of the solid lipid nanoparticles (SLN) with average size 200–300 nm. The smallest SLN size (below 100 nm on average) was obtained in SLN that contained Tego Care and an antimicrobial agent Euxyl PE 9010; such combination evoked synergism between the surfactant and Euxyl components.