Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15 mesoporous silica
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- 作者：Guilan Quana ; b ; Qiaoli Wua ; Xiaoxu Zhanga ; Zhengwen Zhana ; Chan Zhoua ; Bao Chena ; Zhengzan Zhanga ; Ge Lic ; Xin Pana ; pxin_1385@163.com" class="auth_mail" title="E-mail the corresponding author ; Chuanbin Wua ; b ; chuanbin_wu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SBA-15 ; Santa Barbara Amorphous-15 mesoporous silica ; FNB ; fenofibrate ; SEDDS ; self-emulsifying drug delivery system
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：476-482
- 全文大小：1470 K
文摘
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Well-ordered mesoporous silica SBA-15 was synthesized and originally used as inert reservoir for SEDDS.
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The solid SEDDS matrix well retained the self-emulsifying ability, formed a uniform O/W microemulsion when introduced to aqueous media.
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The SEDDS matrix showed faster in vitro release rate than the raw powder and commercial capsule.
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The bioavailability of solid SEDDS matrix was about 4-fold greater than that of commercial products.