Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice
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- 作者：Yingxia Wen ; James Monroe ; Christine Linton ; Jacob Archer ; Clayton W. Beard ; Susan W. Barnett ; Giuseppe Palladino ; Peter W. Mason
- 关键词：Cytomegalovirus ; Pentameric complex ; Vaccine ; Neutralizing antibodies
- 刊名：Vaccine
- 出版年：24 June 2014
- 年：2014
- 卷：32
- 期：30
- 页码：3796-3804
- 全文大小：2320 K
文摘
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- <p id="par0005">Viral replicon particles (VRPs) encoding gH/gL/UL128/UL130/UL131A produce a pentameric protein complex.p>
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- <p id="par0010">Pentameric protein complex was purified from cells transfected with plasmid DNAs encoding the single components.p>
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- <p id="par0015">Sera from mice immunized with pentameric VRPs or the pentameric complex potently neutralize HCMV.p>
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- <p id="par0020">Neutralizing titers elicited by the pentameric complex were superior to those elicited by the gH/gL complex.p>