Effects of acute detoxification of the herbal blend 鈥楽pice Gold鈥?on dopamine D_2/3 receptor availability: A [¹⁸F]fallypride PET study

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• 作者：Axel Rominger ; Paul Cumming ; Guoming Xiong ; Gabriele Koller ; Stefan F枚rster ; Andreas Zwergal ; Evangelos Karamatskos ; Peter Bartenstein ; Christian La Foug猫re ; Oliver Pogarell
• 关键词：Spice ; Cannabinoid ; Addiction ; PET ; Dopamine D2/3 receptor
• 刊名：European Neuropsychopharmacology
• 出版年：November, 2013
• 年：2013
• 卷：23
• 期：11
• 页码：1606-1610
• 全文大小：1505 K

文摘

We carried out dynamic [¹⁸F]fallypride PET scans to measure cerebral dopamine D_2/3 receptor availability in a 23-year old patient experiencing a severe withdrawal syndrome upon voluntary abstinence from 鈥淪pice鈥? a pre-packaged herbal smoking thought to contain synthetic cannabinoids.

Upon admission to the clinic, the patient experienced craving, affective symptoms and a range of somatic complaints, which resolved after several days' monitored abstinence. PET scans were performed on the day of admission, and one week later. Estimates of [¹⁸F]fallypride binding potential (BP_ND) were obtained in striatal and extrastriatal brain regions, and compared to results of age-matched healthy control subjects. Upon admission, [¹⁸F]fallypride BP_ND was reduced by 20% in the patient's striatum and also in extra-striatal regions. During short-term follow-up upon detoxification, the BP_ND increased to normal values.

This study shows substantial short-term alterations of dopamine D_2/3 receptor availability in a patient before and after acute detoxification from 鈥淪pice Gold鈥? thus providing first evidence of reversible effects on dopamine receptors of heavy use of a herbal smoking blend.