Transcriptomic analyses of Hand2 transgenic embryos

详细信息    查看全文

• 作者：Noriko Funato^a ; ^{noriko-funato@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroki Kokubo^b ; ^c ; ^d ; ^{hkokubo@hiroshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yumiko Saga^b ; ^c ; ^{ysaga@nig.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：bHLH ; basic helix-loop-helix ; CAG ; the CMV early enhancer/chicken β actin ; CAT ; chloramphenicol acetyl transferase ; aRNA ; amplified RNA
• 刊名：Genomics Data
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：Complete
• 页码：60-62
• 全文大小：609 K

文摘

In this article, we further provide the data generated for the previously published research article “Specification of jaw identity by the Hand2 transcription factor.” To better understand the downstream genes of the basic helix-loop-helix transcription factor Hand2, we generated double-transgenic mice (Hand2^NC) by intercrossing CAG-floxed CAT-Hand2 mice with Wnt1-Cre mice for conditional activation of Hand2 expression in the neural crest. Altered expression of Hand2 induces transformation of the upper jaw to the lower jaw in Hand2^NC mutant mice. This data article provides Tables detailing the differentially expressed genes between wild-type and Hand2^NC mutant embryos. The raw array data of our transcriptomes as generated using Affymetrix microarrays are available on the NCBI Gene Expression Omnibus (GEO) browser (Reference number GSE75805).