ar0005">A modified reliable Golgi–Cox method is described.
ar0010">It is inexpensive and can be performed in any neuroscience lab.
ar0015">Perfusion–fixation with 4% paraformaldehyde yields good results.
ar0020">Pre-sectioning of perfusion-fixed brain tissue is neither required nor preferred for modified Golgi–Cox staining.
ar0025">We demonstrate reliable changes in striatal dendritic morphology in the Q175 mouse model of Huntington's disease.