Reducing the global burden of HTLV-1 infection: An agenda for research and action

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• 作者：Luc Willems^a ; ^z ; ^{luc.willems@ulg.ac.be} ; Hideki Hasegawa^b ; ^z ; Roberto Accolla^c ; Charles Bangham^d ; Ali Bazarbachi^e ; Umberto Bertazzoni^f ; Anna Barbara de Freitas Carneiro-Proietti^g ; Hua Cheng^h ; Luigi Chieco-Bianchiⁱ ; Vincenzo Ciminaleⁱ ; Jordana Coelho-dos-Reis^j ; José ; Esparza^h ; Robert C. Gallo^h ; Antoine Gessain^k ; Eduardo Gotuzzo^l ; William Hall^m ; Joseph Harfordⁿ ; Olivier Hermine^o ; Steven Jacobson^p ; Beatrice Macchi^q ; Calum Macpherson^r ; Renaud Mahieux^s ; Masao Matsuoka^t ; Edward Murphy^u ; Jean-Marie Peloponese^v ; Viviana Simon^w ; Yutaka Tagaya^h ; Graham P. Taylor^d ; Toshiki Watanabe^x ; Yoshihisa Yamano^y
• 关键词：HTLV-1 ; Vaccine ; Oncogene ; Retrovirus ; Leukemia
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：41-48
• 全文大小：1708 K
• 卷排序：137

文摘

This review outlines priorities and open questions in HTLV research: Review the global prevalence of HTLV-1 infection and identify opportunities and means to expand epidemiological studies. Identify biomarkers to predict disease progression. Develop prophylactic and therapeutic vaccines. Screen for existing and novel drugs to improve therapy. Perform basic research to unravel mechanisms of pathogenesis and open insights into novel treatments.