刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:15 January 2017
年:2017
卷:482
期:3
页码:459-469
全文大小:906 K
卷排序:482
文摘
BCL-2 proteins control the intrinsic or mitochondrial pathway of apoptosis. Defective apoptosis is a hallmark of cancer. BH3-mimetics inhibit pro-survival BCL-2 proteins to induce cancer cell death. ABT-199/venetoclax is approved for treatment of chronic lymphocytic leukaemia.