Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship

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• 作者：Kotaro Sakamoto ; ¹ ; ^{koutarou.sakamoto@takeda.com} ; Satoshi Sogabe¹ ; Yusuke Kamada ; Nozomu Sakai ; Kouhei Asano ; Mie Yoshimatsu ; Kou Ida ; Yasuhiro Imaeda ; Jun-ichi Sakamoto
• 关键词：BCL6 ; PPI ; Peptide ; Phage display
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：310-316
• 全文大小：1625 K
• 卷排序：482

文摘

F1324 was discovered as 5000-times higher affinity peptide to BCL6 than that of BcoR(R498-P514). X-ray crystal structure analysis revealed the binding mode. To our knowledge, F1324 is the strongest BCL6-binding and -inhibition peptide so far.