Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults

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• 作者：James W. Daily ; Ph.D.^a ; Sunmin Park ; Ph.D.^b ; ^{Smpark@hoseo.edu}
• 关键词：BDNF ; Genotypes ; Type 2 diabetes ; Asians ; Energy ; Protein ; Insulin resistance
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：187-194
• 全文大小：255 K
• 卷排序：33

文摘

Brain-derived neurotrophic factor (BDNF) rs6265 Val/Met and Met/Met variants were negatively associated with the risk for type 2 diabetes. Sex and stress levels had an interaction with BDNF Val/Met in the risk for type 2 diabetes. BDNF rs6265 had consistent gene–diet interactions with energy and protein intake. With low-energy, low-protein, and high-carbohydrate intake, BDNF Val/Met lowered the risk for type 2 diabetes. People with BDNF Val/Val are prone to developing type 2 diabetes even in low energy and protein intake in middle-aged adults.