Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes

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• 作者：Michael von Rhein ; MD¹ ; ² ; ³ ; Andreas Buchmann ; PhD⁴ ; Cornelia Hagmann ; MD ; PhD⁵ ; Hitendu Dave ; MD⁶ ; Vera Bernet ; MD³ ; ⁷ ; Ianina Scheer ; MD⁸ ; Walter Knirsch ; MD³ ; ⁹ ; ^&lowast ; ; Beatrice Latal ; MD ; MPH¹ ; ³ ; ^&lowast ; ; on behalf of the Heart ; Brain Research Group^&dagger ; Vera Bernet ; MD ; Christoph Bü ; rki ; MD ; Hitendu Dave ; MD ; René ; Prê ; tre ; MD ; Cornelia Hagmann ; MD ; PhD ; Walter Knirsch ; MD ; Oliver Kretschmar ; MD ; Christian Kellenberger ; MD ; Ianina Scheer ; MD ; Beatrice Latal ; MD ; MPH ; Rabia Liamlahi ; MD ; Michael von Rhein ; MD ; Barbara R. Plecko ; MD ; Felix H. Sennhauser ; MD
• 关键词：CHD ; Congenital heart disease ; MRI ; Magnetic resonance imaging
• 刊名：The Journal of Pediatrics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：167
• 期：6
• 页码：1259-1263.e1
• 全文大小：140 K

文摘

To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.

Study design

Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.

Results

Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).

Conclusions

Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.