Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation

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• 作者：Adrienne M. Antonson^a ; ^b ; Emily C. Radlowski^a ; ^b ; Marcus A. Lawson^a ; ^b ; ^c ; Jennifer L. Rytych^a ; ^b ; Rodney W. Johnson^a ; ^b ; ^c ; ^d ; ^{rwjohn@illinois.edu}
• 关键词：Prenatal ; Maternal immune activation ; Microglia ; Cytokines ; Social behavior ; Piglet
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：300-312
• 全文大小：1922 K
• 卷排序：59

文摘

Maternal infection did not induce aberrant microglia activity in offspring. Maternal infection did not alter offspring response to in vivo LPS challenge. Neonatal spatial learning and memory was not impaired due to maternal infection. Maternal infection altered social behavior in offspring postnatally.