Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax
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- 作者：Sandeepa M. Eswarappa1 ; Alka A. Potdar1 ; 2 ; William J. Koch1 ; Yi Fan1 ; 6 ; Kommireddy Vasu1 ; Daniel Lindner3 ; Belinda Willard4 ; Linda M. Graham5 ; Paul E. DiCorleto1 ; Paul L. Fox1 ; foxp@ccf.org" class="auth_mail
- 刊名：Cell
- 出版年：19 June 2014
- 年：2014
- 卷：157
- 期：7
- 页码：1605-1618
- 全文大小：1937 K
文摘
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Discovery of VEGF-Ax, a novel, antiangiogenic isoform of VEGF-A
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VEGF-Ax is generated by programmed translational readthrough (PTR) of VEGFA mRNA
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Ax is a dual-function RNA element that drives PTR and encodes peptide extension
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PTR is enhanced by hnRNP A2/B1, a trans-acting protein that binds Ax element