Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

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• 作者：Magdalena Hladikova^a ; ^{magdap@centrum.cz} ; Anna Va&#x161 ; k&#x16f ; ^b ; Pavel &#x160 ; tourač ; ^a ; Yvonne Bene&#x161 ; ová ; ^a ; Josef Bednař ; í ; k^a
• 关键词：Multiple sclerosis ; Angiotensin converting enzyme ; Angiotensinogen ; Polymorphism ; Neuroinflammation
• 刊名：Journal of the Neurological Sciences
• 出版年：2011
• 出版时间：15 April 2011
• 年：2011
• 卷：303
• 期：1-2
• 页码：31-34
• 全文大小：151 K

文摘

A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(− 6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS).

We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (− 6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed.

For ACE I/D polymorphism, neither significant differences in the genotype–phenotype study nor in the case–control study were observed.