The Tipping Point for Combination Therapy: Cancer Vaccines With Radiation, Chemotherapy, or Targeted Small Molecule Inhibitors

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• 作者：James W. Hodge ; ^{jh241d@nih.gov} ; Andressa Ardiani ; Benedetto Farsaci ; Anna R. Kwilas ; Sofia R. Gameiro
• 刊名：Seminars in Oncology
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：39
• 期：3
• 页码：323-339
• 全文大小：3050 K

文摘

Therapeutic cancer vaccines are a unique treatment modality in that they initiate a dynamic process of activating the host immune system, which can then be exploited by concurrent or subsequent therapies. The addition of immunotherapy to standard-of-care cancer therapies has shown evidence of efficacy in preclinical models and in the clinical setting. This review examines the preclinical and clinical interactions between vaccine-mediated tumor-specific immune responses and local radiation, systemic chemotherapy, or select small molecule inhibitors, as well as the potential synergy between these modalities.