Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior
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- 作者：Julie Lasselina ; b ; c ; Sigrid Elsenbruchc ; Mats Lekandera ; b ; d ; John Axelssona ; b ; d ; Bianka Karshikoffa ; b ; Jan-Sebastian Grigoleitc ; e ; Harald Englerc ; Manfred Schedlowskic ; Sven Bensonc ; sven.benson@uk-essen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lipopolysaccharide ; Inflammation ; Cytokines ; Interleukin-6 ; Sickness behavior ; Anxiety ; Psychological condition ; STAI ; HADS ; Predictor variables
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：30-37
- 全文大小：853 K
文摘
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LPS administration is well-established to assess behavioral aspects of inflammation.
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We analyzed predictors of LPS-induced state anxiety in a large pooled sample.
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LPS-induced state anxiety increase was predicted by greater cytokine responses.
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Pre-existing anxiety symptoms predicted a lower increase in state anxiety.
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Our findings support a role of inflammation in the pathophysiology of anxiety.