Structural Analysis of Multi-component Amyloid Systems by Chemometric SAXS Data Decomposition

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• 作者：Fá ; tima Herranz-Trillo¹ ; ² ; Minna Groenning² ; ⁴ ; Andreas van Maarschalkerweerd² ; ⁴ ; Romà ; Tauler³ ; Bente Vestergaard² ; ^{bente.vestergaard@sund.ku.dk} ; Pau Bernadó ; ¹ ; ⁵ ; ^{pau.bernado@cbs.cnrs.fr}
• 关键词：amyloids ; small-angle X-ray scattering ; chemometrics ; α-synuclein ; time-dependent oligomerization ; soluble oligomers
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：5-15
• 全文大小：4074 K
• 卷排序：25

文摘

SAXS is sensitive to the oligomeric forms appearing along an amyloidogenic process Mixtures can be chemometrically decomposed using multiple SAXS data representations Conversely to wild-type, α-synuclein E46K forms a large off-pathway disordered oligomer