25 years of advances in the definition, classification and treatment of status epilepticus

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• 作者：Eugen Trinka^a ; ^b ; ^c ; ^{e.trinka@salk.at} ; Reetta Kä ; lviä ; inen^d ; ^e
• 关键词：Status epilepticus ; Classification ; Antiepileptic drugs ; Benzodiazepines ; Anesthetics
• 刊名：Seizure
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：65-73
• 全文大小：1747 K
• 卷排序：44

文摘

Morbidity and mortality of SE correlate with duration of status, the rapid identification of the cause of SE, age and comorbidity. Treatment should be started when a seizure is abnormally prolonged (time-point t1). Time point t1 for generalized tonic clonic seizures is at 5 min, and for focal seizures at 10 min. At time-point t2 neuronal damage may begin, and indicates that SE should be controlled latest by that time. A staged protocol with early, established, refractory and super-refractory stages is the hallmark of current SE treatment.