Rational biosynthetic approaches for the production of new-to-nature compounds in fungi
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- 作者：Simon Boeckera ; b ; simon.boecker@chem.tu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Sophia Zobela ; zobel@chem.tu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Vera Meyerb ; vera.meyer@tu-berlin.de" class="auth_mail" title="E-mail the corresponding author ; Roderich D. Sü ; ssmutha ; roderich.suessmuth@tu-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Secondary metabolite ; Precursor-directed biosynthesis ; Mutasynthesis ; Combinatorial biosynthesis ; Metabolic engineering ; Aspergillus
- 刊名：Fungal Genetics and Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：89-101
- 全文大小：4203 K
文摘
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Fungal secondary metabolites are a rich source for drug development.
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Extension of fungal natural product portfolio by generation of non-natural compounds.
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Description of past and recent strategies for fungal natural product diversification.
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Covering examples from current state-of-the-art biosynthetic approaches.
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Discussion of future challenges and perspectives.