Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice
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- 作者：Indumathi Chennamsetty1 ; Michael Coronado2 ; Ké ; vin Contrepois3 ; Mark P. Keller4 ; Ivan Carcamo-Orive1 ; John Sandin1 ; Giovanni Fajardo2 ; Andrew J. Whittle5 ; Mohsen Fathzadeh1 ; Michael Snyder3 ; Gerald Reaven1 ; Alan D. Attie4 ; Daniel Bernstein2 ; Thomas Quertermous1 ; Joshua W. Knowles1 ; 6 ; knowlej@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAT2 ; Nat1 ; insulin resistance ; mitochondrial dysfunction ; adipose tissue ; fatty acids ; mitochondria ; basal metabolic rate ; reactive oxygen species
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：527-540
- 全文大小：4046 K
文摘
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Absence of the insulin resistance gene Nat1 results in mitochondrial dysfunction
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Nat1 deficiency in mice is associated with a decreased ability to utilize fats for energy
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Nat1-deficient mice have decreased basal metabolic rate and exercise capacity