Nuclear matrix metalloproteinase-2 in the cardiomyocyte and the ischemic-reperfused heart
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- 作者：Sabina Baghirovaa ; baghirov@ualberta.ca" class="auth_mail" title="E-mail the corresponding author ; Bryan G. Hughesa ; b ; bryan.g.hughes@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mathieu Poiriera ; b ; poirier1@ualberta.ca" class="auth_mail" title="E-mail the corresponding author ; Marcia Y. Kondoa ; b ; marciayuri.k@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Richard Schulza ; b ; richard.schulz@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Matrix metalloproteinase-2 ; Nucleus ; Myocardial ischemia ; Reperfusion ; Proteolysis ; Lamin
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：153-161
- 全文大小：440 K
文摘
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Nuclear localization of MMP-2 in cardiomyocytes
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MMP-2 is able to proteolyse lamin A in vitro in a concentration dependent manner.
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Nuclear MMP-2 activity increases during I/R injury of isolated rat hearts.