Dose-dependent effect of cholinotoxin AF64A on the cholinergic elements of the cingulum bundle in rat

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• 作者：Dudas ; Bertalan ; Rose ; Michael ; Hanin ; Israel
• 关键词：Disorders of the nervous system ; Neurotoxicity ; AF64A ; Cingulum bundle ; Choline acetyltransferase ; Animal model ; Alzheimer’ ; s disease
• 刊名：Brain Research
• 出版年：2003
• 出版时间：March 7, 2003
• 年：2003
• 卷：965
• 期：1-2
• 页码：295-298
• 全文大小：161 K

文摘

Previous studies revealed that cholinergic neurons possessing long axons are extremely sensitive to ethylcholine aziridinium ion (AF64A) administration [Neuropharmacology 31 (1992) 397]. In the present paper we examined the effect of AF64A on the cholinergic elements of the cingulum bundle. Seven days after AF64A administration choline acetyltransferase (ChAT)-immunoreactive fibers were extensively damaged on the dorsal part of cingulum bundle. These findings are the first reporting damage by AF64A to this brain region.