Human beta-defensin 1, 2 and 3 production by amniotic epithelial cells with respect to human papillomavirus (HPV) infection, HPV oncogenic potential and the mode of delivery
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- 作者：Dariusz Szukiewicza ; Dariusz.Szukiewicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Habib Alkhalaylab ; Michal Pyzlaka ; Mateusz Watrobaa ; Grzegorz Szewczyka ; Jaroslaw Wejmanc
- 关键词：Human papillomavirus infection ; Human beta-defensins ; Human amniotic epithelial cells ; Pregnancy ; Uterine contraction
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：154-165
- 全文大小：3328 K
文摘
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β-Defensins (HBD) are involved in immune response to HPV infection in pregnancy.
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Risk of HPV DNA transmission to amniotic membrane depends on delivery mode.
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Down-regulated expression of HBD-2 may affect high-risk HPV-related cancerogenesis.
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Therapeutic potential of HBD-2 for high-risk HPV infection should be considered.