An acrylic reline resin loaded with chlorhexidine: Insights on drug release

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• 作者：Ana Francisca Bettencourt^a ; ^{asimao@ff.ul.pt" class="auth_mail" title="E-mail the corresponding author} ; Marina Feliz^a ; Catarina Sousa^b ; Lí ; dia Gonç ; alves^a ; Cristina Bettencourt Neves^b
• 关键词：Acrylic reline resin ; Chlorhexidine ; Controlled release ; Denture stomatitis
• 刊名：Revista Portuguesa de Estomatología, Medicina Dentária e Cirugia Maxilofacial
• 出版年：2016
• 出版时间：July-September 2016
• 年：2016
• 卷：57
• 期：3
• 页码：125-131
• 全文大小：1414 K

文摘

Dental-biomaterials loaded with drugs are a promising strategy for local infection treatment. In this context, some studies suggest the incorporation of chlorhexidine (CHX), as an antifungal drug, in acrylic reline resins for the treatment of m>Candida albicansm> associated dental infections. The purpose of this study was to evaluate the release of CHX from one acrylic reline resin, Kooliner (K). Furthermore, the effect of different media conditions and the drug loading on the CHX release was assessed.

Methods

Resin specimens were prepared from a hard denture reline material based on poly(ethylmethacrylate) (PEMA) and isobutylmethacrylate (IBMA) containing 2.5, 5.0, 7.5 and 10 wt% of CHX. The CHX-loaded resins were incubated in water and artificial saliva (at pH 7) for up to 28 days at 37 °C. Chlorhexidine content was determined by UV-spectroscopy (255 nm).

Results

CHX release was influenced by media composition and drug loading. CHX demonstrated a similar release profile in the two media, however the water showed the higher amount of release in comparison with the inorganic mimetic saliva. CHX release increased proportionally to the concentration of the CHX added, in a linear trend line. Moreover, a high percentage of CHX was not release up to 28 days.

Conclusions

Despite the limitations of the present investigation, results from the present study highlight the need of evaluating drug release not only in water but also in saliva. Strategies that increase the complete release of drug from the material should be investigated in order to prevent the development of multiresistant strains.