Fetuin-A downregulates adiponectin through Wnt-PPARγ pathway in lipid induced inflamed adipocyte

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• 作者：Soumik Agarwal^a ; ¹ ; Mrittika Chattopadhyay^a ; ¹ ; Sandip Mukherjee^a ; ¹ ; Suman Dasgupta^b ; Satinath Mukhopadhyay^c ; Samir Bhattacharya^a ; ^{bhattacharyasa@gmail.com}
• 关键词：Adiponectin ; Fetuin-A ; Wnt3a ; Adipocyte ; PPARγ ; Insulin resistance
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：174-181
• 全文大小：1118 K
• 卷排序：1863

文摘

Mechanism of adiponectin decrease in obesity induced T2D (OID) remains yet unclear. Here we show that FetA inhibited adiponectin expression in inflamed adipocyte. This inhibition by FetA was through upregulation of Wnt3a. FetA enhancement of Wnt3a suppressed PPARγ and adiponectin. FetA inhibition of adiponectin is entirely dependent on Wnt3a.