Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis
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- 作者：Ehud Zigmond1 ; 2 ; Biana Bernshtein1 ; Gilgi Friedlander3 ; Catherine R. Walker4 ; Simon Yona1 ; Ki-Wook Kim1 ; Ori Brenner5 ; Rita Krauthgamer1 ; Chen Varol2 ; Werner Mü ; ller4 ; Steffen Jung1 ; s.jung@weizmann.ac.il" class="auth_mail
- 刊名：Immunity
- 出版年：15 May 2014
- 年：2014
- 卷：40
- 期：5
- 页码：720-733
- 全文大小：4052 K
文摘
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Macrophage production of IL-10 is dispensable for gut homeostasis
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Macrophage sensing of IL-10 is critical for gut homeostasis
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IL-10 is a critical conditioning factor for gut macrophages
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Colonic Treg-derived IL-10 silences macrophages