Reduced frequency of T lymphocytes expressing CTLA-4 in frontotemporal dementia compared to Alzheimer's disease

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• 作者：Rodrigo Ribeiro Santos ; Karen C. Torres ; Giselle S. Lima ; Carolina M. Fiamoncini ; Filipe C. Mapa ; Patricia A. Pereira ; Vitor B. Rezende ; Luiza C. Martins ; Maria A. Bicalho ; Edgar N. Moraes ; Helton J. Reis ; Antonio L. Teixeira ; Marco A. Romano-Silva
• 关键词：AD ; Alzheimer Disease ; APC ; antigen presenting cell ; bvFTD ; behavioural-variant frontotemporal dementia ; CD80 ; B7-1 ; CD86 ; B7-2 ; CNS ; central nervous system ; CTLA-4 ; cytotoxic T-lymphocyte antigen-4 or CD152 ; CTRL ; control patients ; FTD ; Frontotemporal dementia ; HLA-DR ; human leukocyte antigen complex ; MHC ; major-histocompatibility-complex ; MMSE ; Mine-mental state examination ; PBMC ; peripheral blood mononuclear cells ; PNAF ; progressive nonfluent aphasia ; SD ; semantic dementia ; TCR ; T-cell-recept
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：3 January, 2014
• 年：2014
• 卷：48
• 期：Complete
• 页码：1-5
• 全文大小：511 K

文摘

Studies suggest that inflammation is involved in the neurodegenerative cascade of dementias. Immunological mechanisms may be part of the pathophysiological process in frontotemporal dementia (FTD), but up till now only vague evidence of such mechanisms has been presented. The B7- CD28/CTLA-4 pathway is an important immunological signaling pathway involved in modulation of T cell activation. The aim of this study was to compare the expression of molecules associated with co-stimulatory signaling in peripheral blood mononuclear cells (PBMC) of FTD to Alzheimer disease (AD) and control groups. Our results confirm the previous demonstrated increased expression of CD80 in CD14 + Alzheimer patients T cells but show, for the first time, a reduction in the expression of CTLA-4 in CD4 + FTD cells. As CTLA-4 is the most potent negative regulators of T-cell activation we speculated that peripheral T lymphocytes in FTD are more activated and this could be involved in the neurodegeneration observed in this dementia.