Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?
详细信息 查看全文
- 作者：Jorge Amich ; Elaine Bignell
- 刊名：Current Opinion in Microbiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：151-158
- 全文大小：384 K
文摘
- •
- <p id="par0005">Many fungal amino acid biosynthetic pathways are conserved in microbes but absent from humans.p>
- •
- <p id="par0010">Several of the involved enzymes have now been found to be essential for fungal viability.p>
- •
- <p id="par0015">Therapeutic targets must always be tested in systemic disease, currently not commonplace.p>
- •
- <p id="par0020">Much more work required in amino acid biosynthesis in particular in the dimorphic species.p>