A comparison of the binding of three series of nicotinic ligands

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• 作者：Lee ; Mase ; Dukat ; Malgorzata ; Liao ; Liang ; Flammia ; Dwight ; Imad Damaj ; M. ; Martin ; Billy ; Glennon ; Richard A.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：August 5, 2002
• 年：2002
• 卷：12
• 期：15
• 页码：1989-1992
• 全文大小：114 K

文摘

A total of 24 aryl-substituted analogues of nicotine (1a) and two related series of nicotinic ligands, aminomethylpyridines 3 and ether analogues 8, were examined to determine if they bind at α4β2 nACh receptors in a common manner. A modest correlation (r