Synthesis, characterization and biological evaluation of novel Ru(II)-arene complexes containing intercalating ligands
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- 作者：Stefan Nikolića ; 1 ; Loganathan Rangasamyb ; 1 ; Nevenka Gligorijevićc ; Sandra Aranđelovićc ; Sini&scaron ; a Radulovićc ; Gilles Gasserb ; gilles.gasser@chem.uzh.ch" class="auth_mail" title="E-mail the corresponding author ; ; Sanja Grgurić-&Scaron ; ipkaa ; sanjag@chem.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：Anticancer agents ; Bioorganometallic chemistry ; DNA intercalating ligand ; Medicinal inorganic chemistry ; Ruthenium(II)&ndash ; arene complex
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：156-165
- 全文大小：770 K
文摘
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Three new organometallic Ru(II) complexes were synthesized and characterized.
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Two complexes were highly toxic against three cancer cell lines and one non-tumor cell line.
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The mechanism of action of the most potent complex was studied.
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Intracellular accumulation and DNA binding were detected for the most potent complex.