A label-free fluorescence biosensor for highly sensitive detection of lectin based on carboxymethyl chitosan-quantum dots and gold nanoparticles
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- 作者：Ziping Liu ; Hua Liu ; Lei Wang ; Xingguang Su ; suxg@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluorescence biosensor ; Lectins ; CuInS2 QDs ; Au NPs ; Carbohydrate-protein interactions
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：17 August 2016
- 年：2016
- 卷：932
- 期：Complete
- 页码：88-97
- 全文大小：1847 K
文摘
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A label-free near-infrared fluorescence “turn off-on” biosensor for detection of lectin was established.
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The highly sensitive biosensor was based on the inner filter effect of Au NPs on CM-CHIT-QDs.
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Lectin could bind exclusively to CM-CHIT-QDs via multivalent carbohydrate-protein interactions, and “turn on” the fluorescence.
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The biosensor sensor showed good selectivity for the detection of lectin with a low detection limit of 0.07 nM.