The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

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• 作者：Ziv Gan-Or^a ; ^b ; ^c ; ^{ziv.gan-or@mail.mcgill.ca} ; Jacques Y. Montplaisir^d ; ^e ; Jay P. Ross^b ; Judes Poirier^f ; ^g ; Simon C. Warby^d ; ^e ; Isabelle Arnulf^h ; Stephanie Strong^a ; Yves Dauvilliersⁱ ; Claire S. Leblond^a ; ^b ; Michele T.M. Hu^j ; ^k ; Birgit H&ouml ; gl^l ; Ambra Stefani^l ; Christelle Charley Monaca^m ; Valé ; rie Cochen De Cockⁿ ; ^o ; Michel Boivin^p ; ^q ; Luigi Ferini-Strambi^r ; Giuseppe Plazzi^s ; ^t ; Elena Antelmi^s ; Peter Young^u ; Anna Heidbreder^u ; Thomas R. Barber^j ; ^k ; Samuel G. Evetts^j ; ^k ; Michal Rolinski^j ; ^k ; Patrick A. Dion^a ; ^c ; Alex Desautels^d ; ^v ; Jean-Franç ; ois Gagnon^d ; ^w ; Nicolas Dupré ; ^x ; Ronald B. Postuma^c ; ^y ; Guy A. Rouleau^a ; ^b ; ^c
• 关键词：APOE ; REM sleep behavior disorder ; Genetics ; Parkinson's disease ; Dementia with Lewy bodies
• 刊名：Neurobiology of Aging
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：218.e13-218.e15
• 全文大小：203 K
• 卷排序：49

文摘

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88–1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.