Atopic endotype in childhood

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• 作者：Ann-Marie Malby Schoos ; MD ; PhD^a ; Bo Lund Chawes ; MD ; PhD^a ; Morten Arendt Rasmussen ; PhD^a ; ^b ; Joakim Bloch ; MS^a ; Klaus Bø ; nnelykke ; MD ; PhD^a ; Hans Bisgaard ; MD ; DMSc^a ; ^{bisgaard@copsac.com" class="auth_mail" title="E-mail the corresponding author} ;
• 关键词：Endotype ; sensitization ; skin prick test ; specific IgE ; eczema ; asthma ; children
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：137
• 期：3
• 页码：844-851.e4
• 全文大小：1197 K

文摘

The term atopic disorder is an early attempt to define specific endotypes of children with asthma, eczema, or both and increased IgE levels.

Objective

We performed a longitudinal analysis of the relevance of the atopic endotype from birth to age 13 years.

Methods

Allergic sensitization against 28 inhalant and food allergens was assessed at ½, 1½, 4, 6, and 13 years of age in 399 children from the Copenhagen Prospective Study on Asthma in Childhood₂₀₀₀ birth cohort by using both skin prick test responses and specific IgE levels. Asthma and eczema were diagnosed longitudinally by strictly adhering to predefined algorithms. Associations between allergic sensitization, asthma, and eczema were estimated by means of logistic regression, and a machine learning approach was used to identify temporal phenotype clusters of these traits.

Results

Allergic sensitization showed no association with asthma through early childhood (0-6 years) when analyzed as any sensitization (odds ratio [OR] range, 0.78-1.29; P ≥ .48). However, at 13 years of age, any sensitization was associated with asthma (OR range, 4.02-5.94; all P < .001). In contrast, any sensitization was associated with eczema at ½, 1½, and 6 years of age (OR range, 2.06-6.02; P ≤ .01) and borderline associated at 4 years of age (OR, 1.61 [95% CI, 0.96-2.69]; P = .07) but not at 13 years of age (OR, 1.57 [95% CI, 0.78-3.16]; P = .21). We identified 4 latent patterns of disease development that were either dominated by sensitization (37%), eczema (26%), asthma (14%), or healthy status (24%).

Conclusion

We found very little interdependency between asthma, eczema, and allergic sensitization through childhood. The associations between those entities were strongly dependent on age, type of allergens, and method of testing for sensitization. Therefore, atopy in children is unlikely to represent a true endotype.