Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
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- 作者：Christian Stefani ; Zaynab Al-Eisawi ; Patric J. Jansson ; Danuta S. Kalinowski ; danutak@med.usyd.edu.au" class="auth_mail" title="E-mail the corresponding author ; Des R. Richardson ; d.richardson@med.usyd.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Copper ; Bis(thiosemicarbazone) ; Reactive oxygen species ; Lysosome ; Lysosomal membrane permeabilization
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：152
- 期：Complete
- 页码：20-37
- 全文大小：2257 K
文摘
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Bis(thiosemicarbazones) and their Cu complexes have unique anti-cancer activity.
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We examined twelve bis(thiosemicarbazones) to elucidate their mechanisms of action.
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For the first time, we show they mediate lysosomal membrane permeabilization.