Chromosome 11q22.3-q25 LOH in Ovarian Cancer: Association with a More Aggressive Disease Course and Involved Subregions

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• 作者：Launonen ; Virpi ; Stenbä ; ck ; Frej ; Puistola ; Ulla ; Bloigu ; Risto ; Huusko ; Pia ; Kytö ; lä ; Soili ; et. al.
• 刊名：Gynecologic Oncology
• 出版年：1998
• 出版时间：November, 1998
• 年：1998
• 卷：71
• 期：2
• 页码：299-304
• 全文大小：656 K

文摘

Chromosome 11q deletions are common in various malignancies, including ovarian cancer. However, the clinical significance of these genetic lesions as well as their more precise chromosomal location is largely unknown. Here we have examined epithelial ovarian cancer material from 49 patients for loss of heterozygosity (LOH) using nine microsatellite markers on 11q22.3-q25 and evaluated the effect of observed deletions with regard to different clinicopathological variables. LOH was detected in 61 % of the patients. Interestingly, LOH for the D11S1340 marker locus at 11q23.3 seemed to be associated with significantly reduced survival times (P